Negishi coupling reactions as a valuable tool for [11C]methyl-arene formation; first proof of principle.
نویسندگان
چکیده
The Negishi coupling reaction between arylzinc halide reagents and (11)CH3I has been used to synthesise (11)C-methylated arene species via a palladium-mediated process. The metabotropic glutamate receptor subtype-5 radiotracer [(11)C]MPEP has been radiolabelled using this technique.
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عنوان ژورنال:
- Chemical communications
دوره 49 96 شماره
صفحات -
تاریخ انتشار 2013